The Lyu lab investigates how gut microbes and their products communicate with the host to regulate inflammation, cancer development and progression, and responses to cancer immunotherapy. We use multiomic approaches, together with studies of microbial signals and antigen-specific immune responses, to define mechanisms linking host–microbe interactions to disease. Our long-term goal is to uncover new mechanisms and develop therapeutic strategies for cancer and inflammatory diseases.
Identifying novel microbial products and defining the mechanisms by which they influence cancer development and responses to immunotherapy.
Investigating how microbial antigens and antigen-specific immune responses shape inflammation, cancer, and immunotherapy responses.
Translating insights from experimental models to human cancer to identify host–microbe interactions and immune pathways with potential for therapeutic application.
Dr. Mengze Lyu earned his Ph.D. in Cell Biology at Peking University, where he identified manganese as a key regulator of antitumor immunity through activation of the cGAS-STING pathway. He subsequently pursued postdoctoral training with Dr. Gregory F. Sonnenberg at Weill Cornell Medicine, where his research focused on the complex interplay between host immunity and the gut microbiota.
His work has defined the heterogeneity and immunological functions of RORγt⁺ antigen-presenting cells and their roles in immune tolerance and inflammation. Dr. Lyu's long-term goal is to uncover fundamental mechanisms of host–microbe crosstalk in chronic inflammation and cancer, with the ultimate aim of developing novel strategies for cancer and inflammatory disease treatment.
Also published as Lv, Mengze
The Lyu Lab begins its independent research program at Center for Advanced Biotechnology and Medicine.
We are looking for motivated researchers who are excited about host–microbe interactions, immunology, cancer biology, and inflammatory disease.
Prospective postdocs: please send your CV, a brief statement of research interests, and contact information for three references directly to Dr. Lyu.